• Multiple formulation technologies have been developed over time to attempt to address the need: from polymer microspheres, pro-drugs, nano-crystals and also other polymer gels
  • None of these technologies have met the challenges required for a robust delivery platform:
    • Release profiles without “burst” or “lag” effects
    • High drug loading limits allowing drugs to be dosed at the optimal therapeutic range
    • Low manufacturing complexity/cost: high control over quality
    • Because of these limitations, most long acting formulations actually require frequent injections to reach the therapeutic dose – we have developed a technology that overcomes these challenges